The TOP2B Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TOP2B. This antibody recognizes Human, and Mouse antigen. The TOP2B Antibody has been validated for the following applications: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Description: TOP2B Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly ivolved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the type II topoisomerase family.
Function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Subunit Structure: Homodimer (PubMed:21778401). Interacts with KIAA1210 (By similarity).
Similarity: Belongs to the type II topoisomerase family